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Estrogen-Related Receptor γ (ERRγ) Mediates Oxygen-Dependent Induction of Aromatase (CYP19) Gene Expression during Human Trophoblast Differentiation

15 Jul 2011

Abstract excerpt

Differentiation of human cytotrophoblasts to syncytiotrophoblast and the associated induction of aromatase/hCYP19 gene expression are dependent upon a critical O(2) tension; however, the underlying molecular mechanisms remain undefined. In this study, we provide compelling evidence that expression of the orphan nuclear receptor, estrogen-related receptor γ (ERRγ), is also O(2) dependent, induced during human...

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PMID: 21757507
DOI: 10.1210/me.2011-1012

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