Article
Phenotypic and genetic characterization of a next generation live-attenuated yellow fever vaccine candidate.
Vaccine - 9 Sept 2022
Esson Raphael, Rodrigues De Sousa Emanuel, Benair Loic, Devard Nicolas, Soulet Damien, Gillet Audrey, Bassard Isabelle, Falque Stephanie, Chareyre Audrey, Marmin Morgane, Girerd-Chambaz Yves, Logvinoff Carine, Navarro Sanchez Martha Erika
Abstract excerpt
We assessed the genetic and phenotypic characteristics of a yellow fever vaccine candidate, which was cloned from a YF-VAX substrain selected for growth in Vero cells (vYF-247), during the manufacturing process from the master seed lot (MSL) and working seed lot (WSL) through to the drug substance (DS) stage. There were nine minor nucleotide variants observed from the MSL to the DS stage, of which five led to...
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