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Triptolide Down‐regulates COX‐2 Expression and PGE2 Release by Suppressing the Activity of NF‐κB and MAP kinases in Lipopolysaccharide‐treated PC12 Cells

30 Jun 2011

Abstract excerpt

As an active compound extracted from the Chinese herb Tripterygium wilfordii, triptolide (TP) was demonstrated to have potent antiinflammatory and immunosuppressive properties in previous studies. Recently, it has been shown that TP prevented the loss of dopaminergic neurons in the substantia nigra of rats in a model of Parkinson's disease, but little is known about the precise neuroprotective mechanism of TP....

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PMID: 21717513
DOI: 10.1002/ptr.3538

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