Article
Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey.
Thrombosis and haemostasis - 1 Aug 2011
Gurbel Paul A, Tantry Udaya S
Abstract excerpt
Platelet-mediated thrombosis is a dreaded clinical event and is the primary cause of acute coronary syndromes and post-percutaneous intervention (PCI) ischaemic events. There has been a long standing interest in the ex vivo quantification of platelet reactivity to assess the risk of thrombosis. Early studies demonstrated platelet activation and heightened platelet reactivity in acute coronary syndromes and after...
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