Article
Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes.
Haematologica - 1 Oct 2011
Stein Brady L, Williams Donna M, O'Keefe Christine, Rogers Ophelia, Ingersoll Roxann G, Spivak Jerry L, Verma Amit, Maciejewski Jarek P, McDevitt Michael A, Moliterno Alison R
Abstract excerpt
BACKGROUND: The myeloproliferative neoplasms, essential thrombocytosis, polycythemia vera and primary myelofibrosis, share the same acquired genetic lesion, but the concept of JAK2 V617F serving as the sole lesion responsible for these neoplasms is under question, and there has been interest in identifying additional mutations that may contribute to disease pathogenesis. Because ASXL1 lesions have been...
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