Article
NRAMP1 polymorphism and susceptibility to lung tuberculosis in Surabaya, Indonesia.
The Southeast Asian journal of tropical medicine and public health - 1 Mar 2011
Nugraha Jusak, Anggraini Rahayu
Abstract excerpt
The aim of this study was to evaluate the role of three polymorphisms (D543N, TGTG deletion in 3' UTR, INT4 G/C) of NRAMP1 to susceptibility to lung tuberculosis (TB) disease. The results showed that homozygous TGTG deletion in 3'UTR of NRAMP1 was found more frequent in lung tuberculosis patients than in healthy nurses working in a TB ward. This 4 base deletion might cause malfunction of NRAMP1 protein so that it...
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