Article
Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis.
Annals of neurology - 1 Jul 2011
Catoire Hélène, Dion Patrick A, Xiong Lan, Amari Mourabit, Gaudet Rebecca, Girard Simon L, Noreau Anne, Gaspar Claudia, Turecki Gustavo, Montplaisir Jacques Y, Parker J Alex, Rouleau Guy A
Abstract excerpt
Restless legs syndrome (RLS) is a frequent sleep disorder that is linked to disturbed iron homeostasis. Genetic studies identified MEIS1 as an RLS-predisposing gene, where the RLS risk haplotype is associated with decreased MEIS1 mRNA and protein expression. We show here that RNA interference treatment of the MEIS1 worm orthologue increases ferritin expression in Caenorhabditis elegans and that the RLS-associated...
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