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Article

Identification of Fyn as the binding partner for the WASP N-terminal domain in T cells

24 Jun 2011

Abstract excerpt

Wiskott-Aldrich syndrome protein (WASP) plays important roles in TCR signaling. In transgenic (Tg) mice, over-expression of the WASP N-terminal region (exons 1-5) including the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1 (EVH1) domain and anti-WASP-EVH1 single-chain variable fragment (scFv) intracellular expressed antibodies (intrabodies) impairs IL-2 production in activated T cells....

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PMID: 21705469
DOI: 10.1093/intimm/dxr042

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