Article
Integrated next-generation sequencing analysis of whole exome and 409 cancer-related genes.
Biomedical research (Tokyo, Japan) - 1 Jan 2016
Shimoda Yuji, Nagashima Takeshi, Urakami Kenichi, Tanabe Tomoe, Saito Junko, Naruoka Akane, Serizawa Masakuni, Mochizuki Tohru, Ohshima Keiichi, Ohnami Sumiko, Ohnami Shumpei, Kusuhara Masatoshi, Yamaguchi Ken
Abstract excerpt
The use of next-generation sequencing (NGS) techniques to analyze the genomes of cancer cells has identified numerous genomic alterations, including single-base substitutions, small insertions and deletions, amplification, recombination, and epigenetic modifications. NGS contributes to the clinical management of patients as well as new discoveries that identify the mechanisms of tumorigenesis. Moreover, analysis...
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