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DNA Methylation of Tumor Suppressor and Metastasis Suppressor Genes in Circulating Tumor Cells

24 Jun 2011

Abstract excerpt

BACKGROUND: Circulating tumor cells (CTCs) are associated with prognosis in a variety of human cancers and have been proposed as a liquid biopsy for follow-up examinations. We show that tumor suppressor and metastasis suppressor genes are epigenetically silenced in CTCs isolated from peripheral blood of breast cancer patients. METHODS: We obtained peripheral blood from 56 patients with operable breast cancer, 27...

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Identifiers

PMID: 21700955
DOI: 10.1373/clinchem.2011.165902

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