Spermatogonial stem cells alone are not sufficient to re‐initiate spermatogenesis in the rat testis following adjudin‐induced infertility

Abstract excerpt

The blood-testis barrier (BTB) is a unique ultrastructure in the testis, which creates a specialized microenvironment in the seminiferous epithelium known as the apical (or adluminal) compartment for post-meiotic germ-cell development and for maintenance of an immunological barrier. In this study, we have demonstrated unequivocally that a functional and intact BTB is crucial for the initiation of spermatogenesis,...

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