Effect of pretreatment with hepatic mixed-function oxidase inducers on the genotoxicity of four rat carcinogens in the hepatocyte/DNA repair assay.

doi:10.1093/mutage/5.4.387

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Article

Effect of pretreatment with hepatic mixed-function oxidase inducers on the genotoxicity of four rat carcinogens in the hepatocyte/DNA repair assay.

Mutagenesis - 1 Jul 1990

Shaddock J G, Robinson B Y, Casciano D A

Abstract excerpt

Four genotoxic rat carcinogens, previously reported as negative in the standard hepatocyte/DNA repair assay, were studied in hepatocyte cultures derived from the livers of rats pretreated with the hepatic mixed-function oxidase (MFO) inducers, Aroclor (ARO) and 3-methylcholanthrene (3-MC). Cytemb...

Topics

Acrylates
Animals
Aroclors
Carcinogens
Cells, Cultured
DNA Repair
Dose-Response Relationship, Drug
Isomerism
Liver
Male
Methylcholanthrene
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Organophosphonates

Organophosphorus Compounds

Phosphites

Polychlorinated Biphenyls

Rats

Source

Open in PubMed

Identifiers

PMID: 2169015
DOI: 10.1093/mutage/5.4.387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2169015-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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