Article
A reverse transcriptase-related protein mediates phage resistance and polymerizes untemplated DNA in vitro.
Nucleic acids research - 1 Sept 2011
Wang Chen, Villion Manuela, Semper Cameron, Coros Colin, Moineau Sylvain, Zimmerly Steven
Abstract excerpt
Reverse transcriptases (RTs) are RNA-dependent DNA polymerases that usually function in the replication of selfish DNAs such as retrotransposons and retroviruses. Here, we have biochemically characterized a RT-related protein, AbiK, which is required for abortive phage infection in the Gram-positive bacterium Lactococcus lactis. In vitro, AbiK does not exhibit the properties expected for an RT, but polymerizes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.