Article
Coexpression of the human papillomavirus type 16 E4 and L1 open reading frames in early cervical neoplasia.
Virology - 1 Sept 1990
Crum C P, Barber S, Symbula M, Snyder K, Saleh A M, Roche J K
Abstract excerpt
Although the E4 open reading frame (ORF) of human papillomaviruses (HPV) encodes an abundant protein in cutaneous warts, the location and extent of HPV E4 expression in genital precancers, specifically those associated with HPV-16, has not been described. Expression plasmids (pATH) containing segments of the HPV-16 E4 (3401-3620) and L1 (6151-6792) open reading frames (ORFs) were induced and expressed in bacteria...
Topics
- Condylomata Acuminata
- Cytoplasm
- DNA Replication
- DNA, Viral
- Escherichia coli
- Humans
- Immunologic Techniques
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Plasmids