Article
Human lymphatic filariasis: genetic polymorphism of endothelin-1 and tumor necrosis factor receptor II correlates with development of chronic disease.
The Journal of infectious diseases - 15 Jul 2011
Panda Aditya Kumar, Sahoo Prakash Kumar, Kerketta Anna Solami, Kar Santanu Kumar, Ravindran Balachandran, Satapathy Ashok Kumar
Abstract excerpt
BACKGROUND: Hydrocele and elephantiasis are 2 clinically very diverse and often mutually exclusive chronic manifestations of human bancroftian filariasis. Plasma levels of endothelin-1 (ET-1), a major angiogenic factor, and tumor necrosis factor receptors (TNFRs) that regulate host inflammation have been associated with development of chronic filariasis, although their genetic basis are not known. METHODS: We...
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