Article
New insight in protein-ligand interactions. 2. Stability and properties of two mutant forms of the D-galactose/D-glucose-binding protein from E. coli.
The journal of physical chemistry. B - 28 Jul 2011
Stepanenko Olga V, Fonin Alexander V, Stepanenko Olesya V, Morozova Kateryna S, Verkhusha Vladislav V, Kuznetsova Irina M, Turoverov Konstantin K, Staiano Maria, D'Auria Sabato
Abstract excerpt
The galactose/glucose-binding protein from E. coli (GGBP) is a 32 kDa protein possessing the typical two-domains structure of the ligand-binding proteins family. GGBP is characterized by low dissociation constant values with respect to glucose binding, displaying an affinity constant for glucose in micromolar range. This feature makes GGBP unsuitable as a sensitive probe for continuous glucose monitoring in blood...
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