Article
Effect of diamide on polyphosphoinositide metabolism in red blood cells.
Biomedica biochimica acta - 1 Jan 1990
Schwarzer E, Reimann B, Standera S, Jacobasch G
Abstract excerpt
In intact red cells diamide had no strong influence on monoester phosphate group turnover of phosphatidylinositol 4,5-bisphosphate (PIP2), phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid (PA) due to the potent GSH protection of these pathways in vivo. Following the complete GSH oxidation diamide impaired the turnover of PIP and PA dramatically. However that of PIP2 did not show any change. Indeed, a...
Topics
- Azo Compounds
- Diamide
- Erythrocytes
- Glucosephosphate Dehydrogenase Deficiency
- Glutathione
- Humans
- Kinetics
- Mutation
- Phosphatidylinositol Phosphates
- Phosphatidylinositols