Article
FOXO1-FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2011
Liu Jinglan, Guzman Miguel A, Pezanowski Donna, Patel Dilipkumar, Hauptman John, Keisling Matthew, Hou Steve J, Papenhausen Peter R, Pascasio Judy M, Punnett Hope H, Halligan Gregory E, de Chadarévian Jean-Pierre
Abstract excerpt
Rhabdomyosarcoma is the most common pediatric soft tissue malignancy. Two major subtypes, alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma, constitute 20 and 60% of all cases, respectively. Approximately 80% of alveolar rhabdomyosarcoma carry two signature chromosomal translocations, t(2;13)(q35;q14) resulting in PAX3-FOXO1 fusion, and t(1;13)(p36;q14) resulting in PAX7-FOXO1 fusion. Whether the remaining...
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