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Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen‐like secreted proteins in a Rot‐dependent manner

9 Jun 2011

Abstract excerpt

Staphylococcus aureus overproduces a subset of immunomodulatory proteins known as the staphylococcal superantigen-like proteins (Ssls) under conditions of pore-mediated membrane stress. In this study we demonstrate that overproduction of Ssls during membrane stress is due to the impaired activation of the two-component module of the quorum-sensing accessory gene regulator (Agr) system. Agr-dependent repression of...

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PMID: 21651625
DOI: 10.1111/j.1365-2958.2011.07720.x

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