Effect of denervation on the distribution and developmental transition of phosphoglycerate mutase and creatine phosphokinase isozymes in rat muscles of different fiber-type composition.

Abstract excerpt

Phosphoglycerate mutase (PGM) and creatine phosphokinase (CK) occur as three isozymes (types MM, MB and BB) in mammals and these exhibit similar transitions during skeletal muscle development. To study the influence of innervation on this transition and on the maintenance of the isozyme phenotype in mature muscle, we have determined the changes produced by sciatic neurectomy in neonatal and adult rat hindlimb...

Topics

• Animals
• Animals, Newborn
• Bisphosphoglycerate Mutase
• Creatine Kinase
• Hindlimb
• Isoenzymes
• Male
• Muscle Denervation
• Muscle Development
• Muscles
• Phenotype