Article
Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 1997
Zhan W Z, Miyata H, Prakash Y S, Sieck G C
Abstract excerpt
We hypothesized that metabolic adaptations to muscle inactivity are most pronounced when neurotrophic influence is disrupted. In rat diaphragm muscle (Dia(m)), 2 wk of unilateral denervation or tetrodotoxin nerve blockade resulted in a reduction in succinate dehydrogenase (SDH) activity of type I, IIa, and IIx fibers (approximately 50, 70, and 24%, respectively) and a decrease in SDH variability among fibers...
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