Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation.

doi:10.1152/jappl.1997.82.4.1145

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Article

Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 1997

Zhan W Z, Miyata H, Prakash Y S, Sieck G C

Abstract excerpt

We hypothesized that metabolic adaptations to muscle inactivity are most pronounced when neurotrophic influence is disrupted. In rat diaphragm muscle (Dia(m)), 2 wk of unilateral denervation or tetrodotoxin nerve blockade resulted in a reduction in succinate dehydrogenase (SDH) activity of type I...

Topics

Adaptation, Physiological
Animals
Diaphragm
Male
Models, Biological
Muscle Denervation
Muscle Fibers, Fast-Twitch
Muscle Fibers, Skeletal
Muscle Fibers, Slow-Twitch
Myosin Heavy Chains
Myosins
Phenotype
Rats
Rats, Sprague-Dawley
Succinate Dehydrogenase
Tetrodotoxin

Source

Open in PubMed

Identifiers

PMID: 9104851
DOI: 10.1152/jappl.1997.82.4.1145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9104851-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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