Article
Modification of the dystrophic phenotype after transient neonatal denervation: role of MHC isoforms.
Journal of neurobiology - 1 Aug 1992
Ontell M P, Moschella M C, Schiaffino S, Butler-Browne G, Whalen R, Ontell M
Abstract excerpt
While it recently has been demonstrated that it is possible to modify the phenotypic expression of murine dystrophy (dy/dy) (i.e., prevent myofiber loss) by subjecting the extensor digitorum longus (EDL) muscle of 14-day-old dy/dy mice to transient neonatal denervation (Moschella and Ontell, 1987), the mechanism responsible for this phenomenon has not been determined. Since it has been suggested that the effects...
Topics
- Animals
- Animals, Newborn
- Female
- Immunohistochemistry
- Mice
- Mice, Inbred Strains
- Muscle Denervation
- Muscles
- Muscular Dystrophy, Animal
- Myosins
- Phenotype
