Article
Haemophilia management: time to get personal?
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2011
Howard T E, Yanover C, Mahlangu J, Krause A, Viel K R, Kasper C K, Pratt K P
Abstract excerpt
The possibility of alloimmunization in patients receiving protein replacement therapy depends on (at least) three risk factors, which are necessary concomitantly but insufficient alone. The first is the degree of structural difference between the therapeutic protein and the patient's own endogenous protein, if expressed. Such differences depend on the nature of the disease mutation and the pre-mutation endogenous...
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