Article
Population structure of invasive Streptococcus pneumoniae in The Netherlands in the pre-vaccination era assessed by MLVA and capsular sequence typing.
PloS one - 1 Jan 2011
Elberse Karin E M, van de Pol Ingrid, Witteveen Sandra, van der Heide Han G J, Schot Corrie S, van Dijk Anita, van der Ende Arie, Schouls Leo M
Abstract excerpt
The introduction of nationwide pneumococcal vaccination may lead to serotype replacement and the emergence of new variants that have expanded their genetic repertoire through recombination. To monitor alterations in the pneumococcal population structure, we have developed and utilized Capsular Sequence Typing (CST) in addition to Multiple-Locus Variable number tandem repeat Analysis (MLVA).To assess the serotype...
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