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Article

Hierarchical cluster-based partial least squares regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models.

BMC systems biology - 1 Jun 2011

Tøndel Kristin, Indahl Ulf G, Gjuvsland Arne B, Vik Jon Olav, Hunter Peter, Omholt Stig W, Martens Harald

Abstract excerpt

BACKGROUND: Deterministic dynamic models of complex biological systems contain a large number of parameters and state variables, related through nonlinear differential equations with various types of feedback. A metamodel of such a dynamic model is a statistical approximation model that maps variation in parameters and initial conditions (inputs) to variation in features of the trajectories of the state variables...

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Identifiers

PMID: 21627852
DOI: 10.1186/1752-0509-5-90
PMCID: PMC3127793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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