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Article

The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component.

BMC cell biology - 31 May 2011

Jungwirth Michael T, Kumar Dhivya, Jeong Danielle Y, Goodchild Rose E

Abstract excerpt

BACKGROUND: DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein. TorA appears to possess a nuclear envelope (NE) localized activity that requires Lamina-Associated-Polypeptide 1 (LAP1), which is an inner nuclear membrane localized torA-binding partner. Although hypoactive, the DYT1 dystonia torA-ΔE...

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Identifiers

PMID: 21627841
DOI: 10.1186/1471-2121-12-24
PMCID: PMC3164226

Genes

SUN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component.PMID 21627841Read ↗

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