Article
Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast.
PloS one - 1 Jan 2011
Bell Samantha L, Chiang Annette N, Brodsky Jeffrey L
Abstract excerpt
Plasmodium falciparum causes the most virulent form of malaria and encodes a large number of molecular chaperones. Because the parasite encounters radically different environments during its lifecycle, many members of this chaperone ensemble may be essential for P. falciparum survival. Therefore, Plasmodium chaperones represent novel therapeutic targets, but to establish the mechanism of action of any developed...
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