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Article

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

Oncogene - 22 Sept 2011

Lemarie A, Grimm S

Abstract excerpt

Mutations in cancer cells affecting subunits of the respiratory chain (RC) indicate a central role of oxidative phosphorylation for tumourigenesis. Recent studies have suggested that such mutations of RC complexes impact apoptosis induction. We review here the evidence for this hypothesis, which in particular emerged from work on how complex I and II mediate signals for apoptosis. Both protein aggregates are...

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Identifiers

PMID: 21625217
DOI: 10.1038/onc.2011.167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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