Article
Optimum designs for next-generation sequencing to discover rare variants for common complex disease.
Genetic epidemiology - 1 Sept 2011
Shi Gang, Rao D C
Abstract excerpt
Recent advances in next-generation sequencing technologies make it affordable to search for rare and functional variants for common complex diseases systematically. We investigated strategies for enriching rare variants in the samples selected for sequencing so as to optimize the power for their...
Topics
- Computer Simulation
- Family Health
- Female
- Genetic Linkage
- Genetic Variation
- Genetics
- Genome-Wide Association Study
- Humans
- Male
- Microsatellite Repeats
- Molecular Epidemiology
- Phenotype
- Polymorphism, Single Nucleotide
- Research Design
- Sequence Analysis, DNA