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Article

Optimum designs for next-generation sequencing to discover rare variants for common complex disease.

Genetic epidemiology - 1 Sept 2011

Shi Gang, Rao D C

Abstract excerpt

Recent advances in next-generation sequencing technologies make it affordable to search for rare and functional variants for common complex diseases systematically. We investigated strategies for enriching rare variants in the samples selected for sequencing so as to optimize the power for their discovery. In particular, we investigated the roles of alternative sources of enrichment in families through computer...

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Identifiers

PMID: 21618604
DOI: 10.1002/gepi.20597
PMCID: PMC3596871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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