Article
Improvements in Helicobacter pylori eradication rates through clinical CYP2C19 genotyping.
Nagoya journal of medical science - 1 Feb 2011
Tamura Takashi, Kurata Mio, Inoue Shigeru, Kondo Takaaki, Goto Yasuyuki, Kamiya Yoshikazu, Kawai Sayo, Hamajima Nobuyuki
Abstract excerpt
Lansoprazole (LPZ), amoxicillin (AMPC) and clarithromycin (CAM) are commonly used drugs (LAC regimen) for Helicobacter pylori (H. pylori) eradication, but the eradication rate with this regimen was reported to be 70% to 90%. A few studies have reported that a successful eradication was associated with the CYP2C19 genotype, which influences the metabolism of proton pump inhibitors (PPI) including LPZ. This study...
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