Article
Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes.
Breast cancer research and treatment - 1 Apr 2012
Nagel Jord H A, Peeters Justine K, Smid Marcel, Sieuwerts Anieta M, Wasielewski Marijke, de Weerd Vanja, Trapman-Jansen Anita M A C, van den Ouweland Ans, Brüggenwirth Hennie, van I Jcken Wilfred F J, Klijn Jan G M, van der Spek Peter J, Foekens John A, Martens John W M, Schutte Mieke, Meijers-Heijboer Hanne
Abstract excerpt
CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profiling of CHEK2 1100delC breast cancers may reveal clues to the nature of the polygenic CHEK2 model and its genes involved. Here, we report global gene expression profiles of a cohort of 155 familial breast cancers, including 26 CHEK2 1100delC mutant tumors. In line with...
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