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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS

1 Jan 2011

Abstract excerpt

Copper-zinc superoxide dismutase (SOD1) is a detoxifying enzyme localized in the cytosol, nucleus, peroxisomes, and mitochondria. The discovery that mutations in SOD1 gene cause a subset of familial amyotrophic lateral sclerosis (FALS) has attracted great attention, and studies to date have been mainly focused on discovering mutations in the coding region and investigation at protein level. Considering that...

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PMID: 21603028
DOI: 10.1155/2011/458427

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