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Article

TLR2 Mediates the Innate Response of Retinal Muller Glia to Staphylococcus aureus

21 May 2011

Abstract excerpt

Muller cells, the principal glia of the retina, play several key roles in normal and various retinal diseases. To date, their direct involvement in retinal innate defense against bacterial pathogens has not been investigated. In this article, we show that Muller cells express TLR2, a key sensor implicated in recognizing Gram-positive bacteria. We found that intravitreal injection of TLR2 agonist Pam3Cys and...

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PMID: 21602496
DOI: 10.4049/jimmunol.1100565

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