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Article

Disulfide bond prolongs the half-life of therapeutic peptide-GLP-1.

Peptides - 1 Jul 2011

Li Ying, Li Xin, Zheng Xuemin, Tang Lida, Xu Weiren, Gong Min

Abstract excerpt

The multiple physiological characterization of glucagon-like peptide-1 (GLP-1) makes it a promising drug candidate for the therapy of type 2 diabetes. However, the half-life of GLP-1 is short in vivo due to rapid degradation by dipeptidyl peptidase-IV (DPP-IV) and renal clearance. This indicates that the stabilization of GLP-1 is critical for its utility in drug development. In this study, we developed a cluster...

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Identifiers

PMID: 21600946
DOI: 10.1016/j.peptides.2011.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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