Article
Predictors and risk model development for menopausal age in fragile X premutation carriers.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2011
Spath Marian A, Feuth Ton B, Smits Arie P T, Yntema Helger G, Braat Didi D M, Thomas Chris M G, van Kessel Ad Geurts, Sherman Stephanie L, Allen Emily G
Abstract excerpt
PURPOSE: Women who carry a fragile X mental retardation 1 premutation are at risk for fragile X-associated primary ovarian insufficiency and should be counseled for a potentially reduced fertility. Multiple factors can affect the age of onset and severity of fragile X-associated primary ovarian insufficiency. In this study, we assessed the predictive power of several factors with menopausal age, a surrogate...
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