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Article

PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

19 May 2011

Abstract excerpt

BACKGROUND: Huntington disease (HD) is an inherited neurodegenerative disease caused by an abnormal expansion of a CAG repeat in the huntingtin HTT (HD) gene. The primary genetic determinant of the age at onset (AO) is the length of the HTT CAG repeat; however, the remaining genetic contribution to the AO of HD has largely not been elucidated. Recent studies showed that impaired functioning of the peroxisome...

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PMID: 21595933
DOI: 10.1186/1750-1326-6-32

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