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Article

Stable Brain<i>ATM</i>Message and Residual Kinase-Active ATM Protein in Ataxia-Telangiectasia

18 May 2011

Abstract excerpt

The gene that is mutated in ataxia-telangiectasia (A-T), ATM, is catalytically activated in response to DNA damage. Yet a full accounting for the CNS deficits in human A-T or its mouse models remains elusive. We have analyzed the CNS phenotypes of two mouse Atm alleles--Atm(tm1Bal) (Bal) and Atm(tm1Awb) (Awb). Neither mutant has detectable mRNA or protein in peripheral tissues. In brain, although Bal/Bal mice...

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PMID: 21593342
DOI: 10.1523/jneurosci.0778-11.2011

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