Article
Isolation and RNA sequence analysis of cytochrome b mutants resistant to funiculosin, a center i inhibitor of the mitochondrial ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae.
FEBS letters - 9 Apr 1990
di Rago J P, Perea J, Colson A M
Abstract excerpt
Funiculosin is a well-known inhibitor of the mitochondrial respiratory chain, probably acting at the ubiquinone reducing site or center i of QH2-cytochrome c reductase. We report here the isolation, mapping and RNA sequence analysis of yeast apo-cytochrome b mutants resistant to this inhibitor. Funiculosin-resistance was found to be conferred, in 4 independent isolates, upon replacement of a leucine residue by...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Anthraquinones
- Antifungal Agents
- Cytochrome b Group
- Drug Resistance, Microbial
- Electron Transport Complex III
- Intracellular Membranes
- Kinetics