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Article

Evidence for a proatherogenic biochemical phenotype in beta thalassemia minor and intermedia.

Acta haematologica - 1 Jan 2011

Lai Maria Eliana, Vacquer Stefania, Carta Maria Paola, Spiga Alessandra, Cocco Pierluigi, Abete Claudia, Dessì Sandra, Mandas Antonella

Abstract excerpt

The purpose of this study was to focus on pathophysiological mechanisms linking β-thalassemia intermedia (β-TI) and minor (β-TMI) with cardiovascular risk. Iron status, prooxidant-antioxidant balance and lipid profiles in serum, and lipid content in peripheral blood mononuclear cells (PBMCs) were evaluated in 20 β-TMI subjects, 22 β-TI patients and in 30 nonthalassemic blood donors. The mRNA levels of some genes...

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PMID: 21576933
DOI: 10.1159/000327252

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