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Article

Development and characterization of a stable luciferase dengue virus for high-throughput screening.

Antiviral research - 1 Jul 2011

Zou Gang, Xu Hao Ying, Qing Min, Wang Qing-Yin, Shi Pei-Yong

Abstract excerpt

To facilitate dengue virus (DENV) drug discovery, we developed a stable luciferase reporter DENV-2. A renilla luciferase gene was engineered into the capsid-coding region of an infectious cDNA clone of DENV-2. Transfection of BHK-21 cells with the cDNA clone-derived RNA generated high titers (>10(6)PFU/ml) of luciferase reporter DENV-2. The reporter virus was infectious to a variety of cells, producing robust...

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Identifiers

PMID: 21575658
DOI: 10.1016/j.antiviral.2011.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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