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Article

Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome

15 May 2011

Abstract excerpt

BACKGROUND: Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. Approximately 95% of patients with Type 1 diabetes develop some degree of retinopathy within 25 years of diagnosis despite normalization of blood glucose by insulin therapy. The goal of this study was to identify molecular changes in the rodent retina induced by diabetes that are not normalized by insulin replacement and...

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PMID: 21575160
DOI: 10.1186/1755-8794-4-40

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