Article
Disclosure of a stem cell phenotype in an oral squamous cell carcinoma cell line induced by BMP-4 via an epithelial-mesenchymal transition.
Oncology reports - 1 Aug 2011
Qiao Bin, Johnson Newell W, Chen Xiaohua, Li Ruyao, Tao Qian, Gao Jin
Abstract excerpt
A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells, are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrence after treatment. It is unclear whether CSCs can be identified and experimentally induced within oral squamous cell carcinoma (OSCC), although this has been reported for a number of other tumour types....
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