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Article

RAD5a and REV3 function in two alternative pathways of DNA-damage tolerance in Arabidopsis.

DNA repair - 10 Jun 2011

Wang Sheng, Wen Rui, Shi Xianzong, Lambrecht Amanda, Wang Hong, Xiao Wei

Abstract excerpt

DNA-damage tolerance (DDT) in yeast is composed of two parallel pathways and mediated by sequential ubiquitinations of PCNA. While monoubiquitination of PCNA promotes translesion synthesis (TLS) that is dependent on polymerase ζ consisted of a catalytic subunit Rev3 and a regulatory subunit Rev7, polyubiquitination of PCNA by Mms2-Ubc13-Rad5 promotes error-free lesion bypass. Inactivation of these two pathways...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21549648
DOI: 10.1016/j.dnarep.2011.04.009

Genes

DDT
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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