Article
Ancestry of African Americans with sickle cell disease.
Blood cells, molecules & diseases - 15 Jun 2011
Solovieff Nadia, Hartley Stephen W, Baldwin Clinton T, Klings Elizabeth S, Gladwin Mark T, Taylor James G, Kato Gregory J, Farrer Lindsay A, Steinberg Martin H, Sebastiani Paola
Abstract excerpt
The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African...
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