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Article

MicroRNA signatures differentiate melanoma subtypes.

Cell cycle (Georgetown, Tex.) - 1 Jun 2011

Chan Elcie, Patel Rajeshvari, Nallur Sunitha, Ratner Elena, Bacchiocchi Antonella, Hoyt Kathleen, Szpakowski Sebastian, Godshalk Sirie, Ariyan Stephan, Sznol Mario, Halaban Ruth, Krauthammer Michael, Tuck David, Slack Frank J, Weidhaas Joanne Barnes

Abstract excerpt

Melanoma is an aggressive cancer that is highly resistance to therapies once metastasized. We studied microRNA (miRNA) expression in clinical melanoma subtypes and evaluated different miRNA signatures in the background of gain of function somatic and inherited mutations associated with melanoma. Total RNA from 42 patient derived primary melanoma cell lines and three independent normal primary melanocyte cell...

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Identifiers

PMID: 21543894
DOI: 10.4161/cc.10.11.15777
PMCID: PMC3233487

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