Article
Human haptoglobin phenotypes and concentration determination by nanogold-enhanced electrochemical impedance spectroscopy.
Nanotechnology - 17 Jun 2011
Cheng Tsai-Mu, Lee Tzu-Cheng, Tseng Shin-Hua, Chu Hsueh-Liang, Pan Ju-Pin, Chang Chia-Ching
Abstract excerpt
Haptoglobin (Hp) is an acute phase protein that binds free hemoglobin (Hb), preventing Hb-induced oxidative damage in the vascular system. There are three phenotypes in human Hp, whose heterogeneous polymorphic structures and varying concentrations in plasma have been attributed to the cause of diseases and outcome of clinical treatments. Different phenotypes of Hp may be composed of the same subunits but...
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