Article
An evolutionary genomic approach to identify genes involved in human birth timing.
PLoS genetics - 1 Apr 2011
Plunkett Jevon, Doniger Scott, Orabona Guilherme, Morgan Thomas, Haataja Ritva, Hallman Mikko, Puttonen Hilkka, Menon Ramkumar, Kuczynski Edward, Norwitz Errol, Snegovskikh Victoria, Palotie Aarno, Peltonen Leena, Fellman Vineta, DeFranco Emily A, Chaudhari Bimal P, McGregor Tracy L, McElroy Jude J, Oetjens Matthew T, Teramo Kari, Borecki Ingrid, Fay Justin, Muglia Louis
Abstract excerpt
Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm birth is a disorder of profound global health significance. The signals initiating parturition in humans have remained elusive, due to divergence in physiological mechanisms between humans and model organisms typically studied. Because of relatively large human head size and narrow birth canal...
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