Article
Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment.
Biochemical pharmacology - 15 Jul 2011
Gullbo Joachim, Fryknäs Mårten, Rickardson Linda, Darcy Padraig, Hägg Maria, Wickström Malin, Hassan Sadia, Westman Gunnar, Brnjic Slavica, Nygren Peter, Linder Stig, Larsson Rolf
Abstract excerpt
Primary cultures of patient tumor cells (PCPTC) have been used for prediction of diagnosis-specific activity and individual patient response to anticancer drugs, but have not been utilized as a model for identification of novel drugs in high throughput screening. In the present study, ovarian carcinoma cells from three patients were tested in response to a library of 3000 chemically diverse compounds. Eight hits...
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