Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.

Investigative ophthalmology & visual science - 28 Jun 2011

Kolb Aaron W, Schmidt Timothy R, Dyer David W, Brandt Curtis R

Abstract excerpt

PURPOSE: The herpes simplex virus type 1 (HSV-1) U(S)1 gene encodes host-range and ocular virulence determinants. Mutations in U(S)1 affecting virulence are known in strain OD4, but the genomic variation across several strains is not known. The goal was to determine the degree of sequence variation in the gene from several ocular HSV isolates. METHODS: The U(S)1 gene from six ocular HSV-1 isolates, as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Corneal Stroma
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 1, Human

Share to RNA, Viral

Share to Sequence Analysis, DNA

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 21519032
DOI: 10.1167/iovs.10-7032
PMCID: PMC3175936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.PMID 21519032Read ↗

Phylogenetic and Genomic Characterization of Whole Genome Sequences of Ocular Herpes Simplex Virus Type 1 Isolates Identifies Possible Virulence Determinants in Humans.Semantic proximity Read ↗

Quantitative Trait Locus Based Virulence Determinant Mapping of the HSV-1 Genome in Murine Ocular Infection: Genes Involved in Viral Regulatory and Innate Immune Networks Contribute to VirulenceSemantic proximity Read ↗

Multiple determinants contribute to the virulence of HSV ocular and CNS infection and identification of serine 34 of the US1 gene as an ocular disease determinant.Semantic proximity Read ↗

Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution.Semantic proximity Read ↗

Sequence Variability in Clinical and Laboratory Isolates of Herpes Simplex Virus 1 Reveals New MutationsSemantic proximity Read ↗

Genotypic and phenotypic diversity within the neonatal HSV-2 populationSemantic proximity Read ↗

Roles of Us8A and Its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis.Semantic proximity Read ↗

Comparison of strain specific pathogenicity of Herpes Simplex Virus Type 1 by high-throughput sequencing.Semantic proximity Read ↗

Genome Sequence of Herpes Simplex Virus 1 Strain McKraeSemantic proximity Read ↗

Mapping Murine Corneal Neovascularization and Weight Loss Virulence Determinants in the Herpes Simplex Virus 1 Genome and the Detection of an Epistatic Interaction between the UL and IRS/US Regions.Semantic proximity Read ↗

Sequence and comparative analysis of the genome of HSV-1 strain McKrae.Semantic proximity Read ↗

Phylogenetic comparison of exonic US4, US7 and UL44 regions of clinical herpes simplex virus type 1 isolates showed lack of association between their anatomic sites of infection and genotypic/sub genotypic classification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.