Article
Syndromes of resistance to TSH.
Annales d'endocrinologie - 1 Apr 2011
Persani L, Gelmini G, Marelli F, Beck-Peccoz P, Bonomi M
Abstract excerpt
The resistance to TSH action is a genetic disease characterized by molecular defects hampering the adequate transmission of TSH stimulatory signal into thyroid cells. In principle the defect may affect every step along the cascade of events following the binding of TSH to its receptor (TSHR) on thyroid cell membranes. The phenotypic expressivity of TSH resistance is highly variable going from severe congenital...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.